Research Interests
Biophysics of lipid membrane
and application of liposome technology
Techniques:
- Membrane protein binding and activity assays
- Liposome fabrication
- Fluorescence spectroscopy, fluorescence anisotropy, and fluorescence resonance energy transfer (FRET)
- Synchrotron X-ray diffraction
- Quantitative fluorescence microscopy
- Light scattering
- Monte Carlo and Molecular Dynamic computer simulations
Selected Publications:
- Ali, Md R., K. H. Cheng, and J. Huang, 2007. Assess the nature of cholesterol-lipid interactions through the chemical potential of cholesterol in phosphatidylcholine bilayers, Proc Natl Acad Sci USA. 104:5372-5377. [PDF]
- Ali, M.R., K.H. Cheng, and J. Huang. 2006. Ceramide drives cholesterol out of the ordered lipid bilayer phase into the crystal phase in 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine/cholesterol/ceramide ternary mixtures. Biochemistry 45 (41):12629-12638. [PDF]
- Parker, A., K. Miles, K. H. Cheng, and J. Huang. 2004. Lateral Distribution Of Cholesterol In Dioleoylphosphatidylcholine Lipid Bilayers: Cholesterol-Phospholipid Interactions At High Cholesterol Limit. Biophys. J. 86:1532-1544. [PDF]
- Huang, J. 2002. Exploration of Molecular Interactions in Cholesterol Superlattices: Effect of Multibody interactions. Biophys. J. 83, 1014-25.. [PDF]
- Huang, J., and G. W. Feigenson. 1999. A microscopic interaction model of maximum solubility of cholesterol in lipid bilayers. Biophys. J. 76, 2142-57. [PDF]
Research Supports:
- National Science Foundation (NSF) grant
- National Institute of Health (NIH) grant
- Petroleum Research Fund (PRF) grant
- TTU Multidisciplinary Seed grant
- TTU Research Enhancement Fund grant