A large and bright, edge-on spiral galaxy, NGC 4945 in Centaurus, would undoubtably be much better known if it were situated further north. It is bright enough to be visible in binoculars, and in an 8" telescope it appears as a long, featureless patch of light.
The bright galaxy to the left (east) is the 10.1 magnitude NGC 4976. Just above the lefthand end of NGC 4945 is the 15.3 magnitude galaxy PGC 45317. This would be an interesting challenge for a large telescope.