K Kelvin Cheng
Professor of Physics
Molecular Biophysics and Bioengineering Physics

 

Correspondence
K. Kelvin Cheng, Ph.D.
Professor of Physics
Department of Physics
Texas Tech University
Lubbock, Texas 79409-1051
Phone: (806) 742-2992
Fax: (806) 742-1182

email: kelvin.cheng@ttu.edu
Education
Chinese University of Hong Kong, Hong Kong 1974-1978 B.S. (Hon) in Physics

Chinese University of Hong Kong, Hong Kong 1978-1980 M.Phil. in Physics

University of Waterloo, Canada 1980-1983 Ph.D. in Physics

Professional Experience

1983-1984 Postdoctoral Fellow, Pathology Dept., University of Virginia School of Medicine

Purifying and site-specific radio- and fluorescent-labeling of human complement protein C8.

Performing immunoassay of labeled and native C5b-8 and C5b-9 membrane attack complexes on cell membranes.

Performing steady-state and time-resolved fluorescence resonance energy transfer experiments to investigate the kinetics of self-assembling behavior of Human Complement Protein C5b-8 and C5b-9 complexes on biological membranes upon immunoreaction.

1984-1987 Cancer Research Scientist, Biophysics Dept., Roswell Park Cancer Institute, NY

Studying the surface morphologies of nonlamellar phases of synthetic membranes using ultrafast freeze fracture and electron microscopy techniques.

Investigating the structure-dynamics-function relationship of nonlamellar phase preferring lipids in the Ca-transport activities of lipid-modified and reconstituted Ca-ATPase membranes.

Investigating the role of bilayer packing defects in the activities of specific and non-specific lipid-exchange proteins.

1987-1988 Lecturer and Research Assistant Professor, Biochemistry and Physics Depts., SUNY/Buffalo

Teaching General Physics and Modern Physics.

Creating a time-resolved fluorescence spectroscopy research lab.

Studying the nanosecond-resolved orientational dynamics of amphiphilic fluorescent probes in lamellar and nonlamellar phases of synthetic lipid membranes.

Studying the morphology and structure of bilayer packing defects using electron microscopy.

1988-1992 Assistant Professor, 1992-1997 Associate Professor, 1997- Professor, Physics Dept., TTU

Teaching undergraduate and graduate Physics.

Exploring the effect of Internet Technology on the student understanding of physics concepts in introductory physics class.

Creating a molecular spectroscopy biophysics lab.

Studying headgroup hydration and orientational dynamics and distribution of cylindrically symmetric fluorophores in membranes of different packing symmetries.

Detecting and characterizing lipid packing defects and nonlamellar structures using nanosecond-resolved intramolecular excimer fluorescence spectroscopy and FTIR.

Creating 3-state intramolecular excimer kinetic model of pyrene molecules in liquid crystalline materials.

Development of MR diffusion and relaxation imaging methods (MR pulse design and image calculations).

Designing a nanosecond-resolved frequency-domain fluorescence lifetime imaging system.

Studying Lateral Domain Formation of Self-assembly Bilayers.

Studying Single Calcium Channel Electrophysiology on Free-Standing Single Lipid Planar Bilayer.

Creating and Developing 3-Dimensional MR Gel Dosimetry for Dose Verification of Conformal Radiation Therapy.
 

Creating and Developing "Lab on Chip"

Previous and Current Research Supports

American Heart Association Postdoctoral Fellowship
NIH-BRSG
NSF- Instrumentation Grant
NIH-FIRST Award (5-year Career Development Award)
Robert A. Welch Research Foundation
Research Agreement with Advanced DNA Technologies Inc.
NIJ

Invited Reviewer

National Sciences and Engineering Research Council of Canada
National Science Foundation
Israel Science Foundation (Biophysics Program)
American Chemical Society (Petroleum Research Fund)
Research Corporation
NIH - NCRR Study Section
NIH - NIAAA Study Section

Mount Sinai School of Medicine
Biophysics Journal, BBA, J. Physical Chemistry and Biophysical Chemistry
Texas Higher Education Coordination Board

Recently Invited Presentations

Center of Excellence in Biomedical Engineering, Harvard School of Medicine
Keynote speaker in SPIE conference
Physics Dept., Emery University
Physics Dept., Texas Christian University
Biomath Dept., Mount Sinai School of Medicine at NYC
Physics Department, Trinity University at San Antonio
National AAPT meeting
University of Waterloo and University of Toronto

Current Research Collaborators

Dr. Pentti Somerharju, Dept. of Medical Chemistry, University of Helsinki, Finland
Dr. Jorma Virtanen, Department of Chemistry, Division of Nanoscience, University of Jyväskylä, Finland

Peer-reviewed Publications (over 50)

(For a complete list of publications, click "List of Publications" on the Left menu bar.)

Representative Publications

Cannon, B., A. Lewis, J. Metze, V. Thiagarajan, M.W. Vaughn, P. Somerharju, J. Virtanen, J. Huang and K.H. Cheng. 2006. Cholesterol supports headgroup superlattice domain formation in fluid phospholipid/cholesterol bilayers. J. Phys. Chem. (in press)

Cannon, B., N. Weaver, Q. Pu, V. Thiagarajan, S Liu, J. Huang, M. W. Vaughn, and K. H Cheng.2005. Cholesterol modulated antibody binding in supported lipid membranes as determined by total internal reflectance microscopy on a microfabricated high-throughput glass chip. Langmuir. 21:9666-9674.

Cheng, K., B. A. Thacker, R. L. Cardenas, and C. Crouch..2003. Implementation of interactive online homework significantly enhances student's learning of physics concepts in an introductory physics course. American Journal of Physics-PER (pending)

Cannon, B., M. Hermansson, S, Gyorke, P. Sommerharju, J.Virtanen, and K. H. Cheng. 2003. Regulation of calcium channel activity by lipid domain formation in Planar Lipid Bilayers. Biophysical Journal . 85: 933-942.

Brian Cannon, Garrette Heath, Juyang Huang, Pentti Somerharju, Jorma Virtanen, and Kwan Hon Cheng. 2003. Time-Resolved Fluorescence and Fourier Transform Infrared Spectroscopic Investigations of Lateral Packing Defects and Superlattice Domains and in Compositionally Uniform Cholesterol/Phosphatidylcholine Bilayers. Biophysical. Journal . 84: 3777-3791.

Cardenas, R. L., K. H. Cheng, L. J. Verhey, P. Xia, L. davis, and B. Cannon. 2002. A self consistent normalized calibration protocol for three dimensional magnetic resonance gel dosimetry. Magn. Reson. Imaging. 20: 667-679

Tanhuanpaa K., K. Cheng, J. Virtanen, K. Anttonen and P. Somerharju. 2001. Characteristics of Pyrene Phospholipid/gama-Cyclodextrin Complex. Biophysical Journal 81: 1051-1510.

Cardenas, R.L., K.H. Cheng and K. Sack. 2001. The Effects of Cidofovir on Progressive Multifocal Leukoencephalopathy: an MRI case Study. Neuroradiology 43: 379-382.

Menzel, E. R., S. M. Savoy, S. J. Ulvick, K.H. Cheng, R. H. Murdock, M. R., Sudduth. 2000. Photoluminescent Semiconductor Nanocrystals for Fingerprint Detection. J. Forensic Science 45: 545-551.

Menzel, E. R., M. Takatsu, R.H. Murdock, K. Bouldin and K.H. Cheng. 2000. Photoluminescent CdS/Dendrimer Nanocomposites for Fingerprint Detection. J. Forensic Science 45:770-773.

Cheng, K.H., J. Virtanen and P. Somerharju. 1999. Fluorescence Studies of Dehydroergosterol in Phosphatidylethanolamine/Phosphatidylcholine Bilayers. Biophysical Journal 77: 3108-3119.

Somerharju, P., J. A. Virtanen and K.H. Cheng. 1999. Lateral Organization of membrane Lipids. The Superlattice View. (Review) Biochimica et Biophysica Acta 1440: 32-48.

Virtanen, J.A., K.H. Cheng and P. Somerharju. 1998. Phospholipid composition of the mammalian red cell membrane can be rationalized by a superlattice model. Proc. Natl. Acad. Sci. USA. 95: 4964-4969.

Cheng, K.H., M. Ruonala, J. Virtanen, and P. Somerharju. 1997. Evidence for superlattice arrangements in fluid phosphatidylcholine/phosphatidylethanolamine Bilayers. Biophysical Journal 73: 1967-1976.

Chen, S.-Y. and K.H. Cheng. 1996. Detection of membrane packing defects by time-resolved fluroescence depolarization. Biophysical Journal 71: 878-884.

Cheng, K.H., and P. Somerharju. 1996. Effects of unsaturation and curvature on the transverse distribution of intramolecular dynamics of dipyrenyl lipids. Biophysical Journal 70: 2287-2298.

Students and Postdocs trained: (more than 12)

(For a complete list of teaching activities, click "Teaching" on the Left Menu bar)


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